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In LSD-25 (lysergic acid diethylamide) the phar­macologists have recently created another aspect of soma — a perception-improver and vision-producer that is, physiologically speaking, almost costless. This ex­traordinary drug, which is effective in doses as small as fifty or even twenty-five millionths of a gram, has power (like peyote) to transport people into the other world. In the majority of cases, the other world to which LSD-25 gives access is heavenly; alternatively it may be purgatorial or even infernal. But, positive, or negative, the lysergic acid experience is felt by al­most everyone who undergoes it to be profoundly significant and enlightening. In any event, the fact that minds can be changed so radically at so little cost to the body is altogether astonishing.

Soma was not only a vision-producer and a tranquil­lizer; it was also (and no doubt impossibly) a stimu­lant of mind and body, a creator of active euphoria as well as of the negative happiness that follows the re­lease from anxiety and tension.

The ideal stimulant — powerful but innocuous — still awaits discovery. Amphetamine, as we have seen, was far from satisfactory; it exacted too high a price for what it gave. A more promising candidate for the role of soma in its third aspect is Iproniazid, which is now being used to lift depressed patients out of their misery, to enliven the apathetic and in general to in­crease the amount of available psychic energy. Still more promising, according to a distinguished phar­macologist of my acquaintance, is a new compound, still in the testing stage, to be known as Deaner. Deaner is an amino-alcohol and is thought to increase the production of acetyl-choline within the body, and thereby to increase the activity and effectiveness of the nervous system. The man who takes the new pill needs less sleep, feels more alert and cheerful, thinks faster and better — and all at next to no organic cost, at any rate in the short run. It sounds almost too good to be true.

We see then that, though soma does not yet exist (and will probably never exist), fairly good substi­tutes for the various aspects of soma have already been discovered. There are now physiologically cheap tranquillizers, physiologically cheap vision-producers and physiologically cheap stimulants.

That a dictator could, if he so desired, make use of these drugs for political purposes is obvious. He could ensure himself against political unrest by changing the chemistry of his subjects' brains and so making them content with their servile condition. He could use tranquillizers to calm the excited, stimulants to arouse enthusiasm in the indifferent, halluciants to distract the attention of the wretched from their miseries. But how, it may be asked, will the dictator get his subjects to take the pills that will make them think, feel and behave in the ways he finds desirable? In all probabil­ity it will be enough merely to make the pills available. Today alcohol and tobacco are available, and people spend considerably more on these very unsatisfactory euphorics, pseudo-stimulants and sedatives than they are ready to spend on the education of their children. Or consider the barbiturates and the tranquillizers. In the United States these drugs can be obtained only on a doctor's prescription. But the demand of the Ameri­can public for something that will make life in an urban-industrial environment a little more tolerable is so great that doctors are now writing prescriptions for the various tranquillizers at the rate of forty-eight millions a year. Moreover, a majority of these prescrip­tions are refilled. A hundred doses of happiness are not enough: send to the drugstore for another bottle — and, when that is finished, for another. . . . There can be no doubt that, if tranquillizers could be bought as easily and cheaply as aspirin, they would be con­sumed, not by the billions, as they are at present, but by the scores and hundreds of billions. And a good, cheap stimulant would be almost as popular.

Under a dictatorship pharmacists would be in­structed to change their tune with every change of circumstances. In times of national crisis it would be their business to push the sale of stimulants. Between crises, too much alertness and energy on the part of his subjects might prove embarrassing to the tyrant. At such times the masses would be urged to buy tran­quillizers and vision-producers. Under the influence of these soothing syrups they could be relied upon to give their master no trouble.

As things now stand, the tranquillizers may prevent some people from giving enough trouble, not only to their rulers, but even to themselves. Too much tension is a disease; but so is too little. There are certain occasions when we ought to be tense, when an excess of tranquillity (and especially of tranquillity imposed from the outside, by a chemical) is entirely inappropri­ate.

At a recent symposium on meprobamate, in which I was a participant, an eminent biochemist playfully suggested that the United States government should make a free gift to the Soviet people of fifty billion doses of this most popular of the tranquillizers. The joke had a serious point to it. In a contest between two populations, one of which is being constantly stimu­lated by threats and promises, constantly directed by one-pointed propaganda, while the other is no less con­stantly being distracted by television and tranquillized by Miltown, which of the opponents is more likely to come out on top?

As well as tranquillizing, hallucinating and stimulat­ing, the soma of my fable had the power of heighten­ing suggestibility, and so could be used to reinforce the effects of governmental propaganda. Less effectively and at a higher physiological cost, several drugs al­ready in the pharmacopoeia can be used for the same purpose. There is scopolamine, for example, the active principle of henbane and, in large doses, a powerful poison; there are pentothal and sodium amytal. Nick­named for some odd reason "the truth serum," pento­thal has been used by the police of various countries for the purpose of extracting confessions from (or per­haps suggesting confessions to) reluctant criminals. Pentothal and sodium amytal lower the barrier be­tween the conscious and the subconscious mind and are of great value in the treatment of "battle fatigue" by the process known in England as "abreaction ther­apy," in America as "narcosynthesis." It is said that these drugs are sometimes employed by the Commu­nists, when preparing important prisoners for their public appearance in court.

Meanwhile pharmacology, biochemistry and neurol­ogy are on the march, and we can be quite certain that, in the course of the next few years, new and better chemical methods for increasing suggestibility and lowering psychological resistance will be dis­covered. Like everything else, these discoveries may be used well or badly. They may help the psychiatrist in his battle against mental illness, or they may help the dictator in his battle against freedom. More probably (since science is divinely impartial) they will both en­slave and make free, heal and at the same time destroy.

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